Bracketology by Jonathon Warriner
Updated February 26th, 2022
| West Region (San Francisco) | South Region (San Antonio) |
| 1.Gonzaga (Portland) | 1.Arizona (San Diego) |
| 16.Texas Southern/ New Orleans | 16.Long Beach State |
| 8.Wyoming | 8.St. Mary’s |
| 9.Creighton | 9.Boise State |
| 4.UCLA (San Diego) | 4.Illinois (Buffalo) |
| 13.New Mexico State | 13.Chattanooga |
| 5.Houston | 5.Alabama |
| 12.Loyola-Chicago | 12.Memphis/ North Carolina |
| 3.Wisconsin (Pittsburgh) | 3.Tennessee (Milwaukee) |
| 14.Princeton | 14.Wagner |
| 6.Arkansas | 6.USC |
| 11.North Texas | 11.Notre Dame |
| 2.Duke (Greenville) | 2.Baylor (Fort Worth) |
| 15.Norfolk State | 15.Montana State |
| 7.Iowa State | 7.Marquette |
| 10.San Francisco | 10.Wake Forest |
| East Region (Philadelphia) | Midwest Region (Chicago) |
| 1.Auburn (Greenville) | 1.Kansas (Fort Worth) |
| 16.Colgate/ UNC Wilmington | 16.Cleveland State |
| 8.Michigan State | 8.Seton Hall |
| 9.Xavier | 9.Davidson |
| 4.Providence (Buffalo) | 4.UConn (Portland) |
| 13.Vermont | 13.South Dakota State |
| 5.Texas | 5.Ohio State |
| 12.Iona | 12.Oregon/ San Diego State |
| 3.Texas Tech (Milwaukee) | 3.Villanova (Pittsburgh) |
| 14.Texas State | 14.Ohio |
| 6.Colorado State | 6.Murray State |
| 11.SMU | 11.Michigan |
| 2.Purdue (Indianapolis) | 2.Kentucky (Indianapolis) |
| 15.Liberty | 15.Longwood |
| 7.LSU | 7.Iowa |
| 10.Miami | 10.TCU |
NIT One Seeds: VCU, Indiana, Rutgers, BYU
The Next Five: Florida, Dayton, Virginia Tech, Kansas State, Virginia