Bracketology by Jonathon Warriner
Updated February 27th, 2022
| West Region (San Francisco) | South Region (San Antonio) |
| 1.Gonzaga (Portland) | 1.Arizona (San Diego) |
| 16.Texas Southern/ New Orleans | 16.Long Beach State |
| 8.Wyoming | 8.Iowa |
| 9.TCU | 9.Boise State |
| 4.UCLA (San Diego) | 4.UConn (Portland) |
| 13.New Mexico State | 13.South Dakota State |
| 5.Texas | 5.Ohio State |
| 12.Loyola-Chicago | 12.San Diego State/ Memphis |
| 3.Tennessee (Pittsburgh) | 3.Texas Tech (Milwaukee) |
| 14.Princeton | 14.Wagner |
| 6.Houston | 6.St. Mary’s |
| 11.Notre Dame | 11.Miami |
| 2.Purdue (Indianapolis) | 2.Auburn (Greenville) |
| 15.Liberty | 15.Norfolk State |
| 7.Murray State | 7.Marquette |
| 10.Creighton | 10.Wake Forest |
| East Region (Philadelphia) | Midwest Region (Chicago) |
| 1.Kansas (Fort Worth) | 1.Baylor (Fort Worth) |
| 16.Colgate/ UNC Wilmington | 16.Cleveland State |
| 8.Michigan State | 8.Seton Hall |
| 9.Xavier | 9.Davidson |
| 4.Providence (Buffalo) | 4.Illinois (Buffalo) |
| 13.Vermont | 13.Chattanooga |
| 5.Alabama | 5.Arkansas |
| 12.North Carolina/ VCU | 12.Iona |
| 3.Villanova (Pittsburgh) | 3.Wisconsin (Milwaukee) |
| 14.Ohio | 14.Texas State |
| 6.USC | 6.Colorado State |
| 11.SMU | 11.North Texas |
| 2.Duke (Greenville) | 2.Kentucky (Indianapolis) |
| 15.Longwood | 15.Montana State |
| 7.LSU | 7.Iowa State |
| 10.Michigan | 10.San Francisco |
NIT One Seeds: Indiana, Florida, Virginia Tech, Oregon
The Next Five: Rutgers, BYU, Belmont, Oklahoma, Colorado