Bracketology by Jonathon Warriner
Updated February 28th, 2022
| West Region (San Francisco) | South Region (San Antonio) |
| 1.Gonzaga (Portland) | 1.Baylor (Fort Worth) |
| 16.Nicholls State/ Texas Southern | 16.Norfolk State/ Bryant |
| 8.Marquette | 8.Seton Hall |
| 9.Wyoming | 9.Davidson |
| 4.UCLA (San Diego) | 4.Arkansas (Portland) |
| 13.New Mexico State | 13.Northern Iowa |
| 5.Texas | 5.St. Mary’s |
| 12.South Dakota State | 12.Indiana/ San Diego State |
| 3.Texas Tech (Milwaukee) | 3.Tennessee (Pittsburgh) |
| 14.Liberty | 14.Princeton |
| 6.Colorado State | 6.Ohio State |
| 11.Notre Dame | 11.Memphis |
| 2.Purdue (Indianapolis) | 2.Duke (Greenville) |
| 15.Colgate | 15.Longwood |
| 7.Murray State | 7.Michigan State |
| 10.Creighton | 10.VCU |
| East Region (Philadelphia) | Midwest Region (Chicago) |
| 1.Arizona (San Diego) | 1.Kansas (Fort Worth) |
| 16.Cal State Fullerton | 16.Cleveland State |
| 8.Boise State | 8.LSU |
| 9.TCU | 9.Xavier |
| 4.Illinois (Buffalo) | 4.Providence (Buffalo) |
| 13.Chattanooga | 13.Vermont |
| 5.UConn | 5.Houston |
| 12.Iona | 12.Wake Forest/ Michigan |
| 3.Villanova (Pittsburgh) | 3.Wisconsin (Milwaukee) |
| 14.Toledo | 14.Texas State |
| 6.Alabama | 6.USC |
| 11.Miami | 11.North Texas |
| 2.Auburn (Greenville) | 2.Kentucky (Indianapolis) |
| 15.UNC Wilmington | 15.Montana State |
| 7.Iowa | 7.Iowa State |
| 10.North Carolina | 10.San Francisco |
NIT One Seeds: SMU, Oregon, BYU, Rutgers
The Next Five: Florida, Virginia Tech, Loyola-Chicago, Oklahoma, Colorado